The HTC Desire had striking similarities to the Google-branded
Nexus One which was also made by HTC.
Like the Nexus One, the Desire has a 3.7-inch AMOLED touch screen and a 1GHz Qualcomm Snapdragon processor, but the Nexus One's trackball was replaced by an optical sensor and its soft buttons were replaced by keys.
Due to a shortage of AMOLED displays in mid-2010, HTC changed the Desire’s display to a S-LCD panel. It claimed the S-LCD display improved the readability of the screen due to “improved effective resolution” addressing one of the shortcomings of the AMOLED display which was hard to read in direct sunlight. HTC also claimed the S-LCD panel was more power-efficient, but ultimately this depended on usage conditions.
The Desire used HTC’s proprietary user interface, Sense which it had developed to work on top of the Android OS. The Desire saw the arrival of the latest version of Sense UI offering more integrated access to social networks. It also delivered improved navigation through a "leap" function that allowed a user to display thumbnails of all seven standby screens by using a pinch gesture on the home screen. It also had embedded support for Flash Player 10.1, and text reflow, which intelligently redrew text when users zoomed in.
HTC's confidence in this product was reflected by the strong operator support it received. When it was announced HTC claimed it would be offered by "almost every key operator in countries where HTC was present".